United States securities and exchange commission logo May 15, 2024 Benjamin Stilwill Chief Executive Officer Streamline Health Solutions, Inc. 2400 Old Milton Pkwy., Box 1353 Alpharetta, GA 30009 Re: Streamline Health Solutions, Inc. Registration Statement on Form S-3 Filed May 7, 2024 File No. 333-279190 Dear Benjamin Stilwill: We have conducted a limited review of your registration statement and have the following comment. Please respond to this letter by amending your registration statement and providing the requested information. If you do not believe our comment applies to your facts and circumstances or do not believe an amendment is appropriate, please tell us why in your response. After reviewing any amendment to your registration statement and the information you provide in response to this letter, we may have additional comments. Form S-3 filed May 7, 2024 Selling Securityholders, page 8 1. Please disclose the natural person or persons who exercise sole or shared voting and/or dispositive powers with respect to the shares held by Resilient Holding LLC and Tammaro Realty LLC. Also, please identify any selling stockholder that is a registered broker-dealer or an affiliate of a broker-dealer. Please note that a registration statement registering the resale of shares being offered by a broker-dealer must identify the broker- dealer as an underwriter if the shares were not issued as underwriting compensation. For a selling stockholder that is an affiliate of a broker-dealer, your prospectus must state, if true, that: (1) the seller purchased the securities in the ordinary course of business; and (2) at the time of purchase of the securities you are registering for resale, the seller had no agreements or understandings, directly or indirectly, with any person, to distribute the securities. If you are unable to make these statements in the prospectus, please disclose Benjamin Stilwill Streamline Health Solutions, Inc. May 15, 2024 Page 2 that the selling stockholder is an underwriter. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Refer to Rule 461 regarding requests for acceleration. Please allow adequate time for us to review any amendment prior to the requested effective date of the registration statement. Please contact Marion Graham at 202-551-6521 or Matthew Crispino at 202-551-3456 with any other questions. FirstName LastNameBenjamin Stilwill Sincerely, Comapany NameStreamline Health Solutions, Inc. Division of Corporation Finance May 15, 2024 Page 2 Office of Technology FirstName LastName