November 15, 2019 Thomas J. Gibson Chief Financial Officer Streamline Health Solutions, Inc. 1175 Peachtree Street, NE, 10th Floor Atlanta GA, 30361 Re: Streamline Health Solutions, Inc. Registration Statement on Form S-3 Filed November 7, 2019 File No. 333-234567 Dear Mr. Gibson: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Matthew Derby, Staff Attorney, at (202) 551-2224 or, in his absence, Jan Woo, Legal Branch Chief, at (202) 551-3453 with any questions. Sincerely, Division of Corporation Finance Office of Technology cc: David Ghegan